Defining a New Discipline

Perioperative health.

Medicine has organized itself around the surgical event. The procedure. The technique. The outcome in the OR. What happens to the patient in the weeks surrounding surgery — physiologically, nutritionally, systemically — has never had a discipline of its own. PERIOME is defining that category.

50M+ Surgical procedures in
the U.S. each year

<1% Receive structured
perioperative preparation

0 Widely adopted patient-facing
perioperative protocols before PERIOME

The Oversight

Surgery is one of the most profound physiologic demands a human body will ever face. Medicine built a system for the procedure. Not for the patient's body around it.

The surgical experience is shaped long before the first incision and long after the last suture. Nutritional status, gut integrity, electrolyte balance, neurocognitive readiness, and cellular energy reserves all influence how a patient tolerates anesthesia, responds to surgical stress, and moves through recovery. This is not speculative. It is a well-documented area of perioperative medicine.

And it is still inconsistently addressed in routine care.

The gap is not clinical knowledge. The science of perioperative nutrition and physiologic support is well established in academic literature. The gap is infrastructure — no one built the protocol, the product, or the delivery system to place that knowledge in the hands of the patient and the physician at the moment it matters.

That is what PERIOME exists to build.

Nutritional depletion begins before the procedure

Pre-operative fasting, anxiety, and altered eating patterns deplete electrolytes, glycogen, and micronutrient reserves in the days before surgery — before a single incision is made.

Surgical stress is a total-body physiologic event

Anesthesia, tissue trauma, and the post-operative inflammatory response place simultaneous demands on multiple organ systems. Nutritional and metabolic status directly shapes how the body meets those demands.

Recovery is an active physiologic process

The post-operative period is not passive. Gut function, immune activity, cognitive recovery, and tissue repair are active physiologic processes unfolding in real time — with or without structured support.

This window remains without a standard

ERAS protocols address selected intraoperative and immediate post-operative factors. A broadly adopted, patient-facing protocol for the full perioperative nutritional and physiologic preparation window has never been built. That is what PERIOME is building.

Days −7 to −1 · Pre-Operative

Prepare.

The pre-operative window is a high-leverage period. Electrolyte loading, gut support, metabolic support, cognitive precursor support, and micronutrient repletion in this phase prepare the body for the physiologic demands of anesthesia and surgical stress. It is the window most consistently left unaddressed in routine care.

Days +1 to +7 · Post-Operative

Recover.

Post-operative recovery is not passive. Immune activity, tissue repair, gut reestablishment, and neurocognitive recovery are active physiologic processes with defined timelines and defined nutritional demands. Structured support in this window matters. PERIOME PROTOCOL is built to provide it.

Day −7 Surgery Day +7

Physiologic demand relative to baseline

Care is organized by specialty, not by patient arc

Surgeons own the procedure. Anesthesiologists manage intraoperative physiology. Primary care may see the patient later. No specialty consistently owns the perioperative period as a whole — and so the patient often moves through it without a guide, a protocol, or a standard of support.

No commercial infrastructure existed to act on the science

The supplement and wellness industries serve chronic health — daily habits, long-term optimization, general wellbeing. No one built products for the acute, defined, time-limited demands of the surgical patient. The gap was not just commercial. It was categorical.

Incentives stop at the hospital door

Healthcare systems are measured on procedural outcomes and complication rates. Patient preparation that happens at home — in the days before admission — is less visible to those metrics and therefore less consistently addressed. PERIOME operates in the space the system has historically left unserved.

Category Ownership

Defining the standard

PERIOME is not entering the supplement market. We are building a category — perioperative health — establishing the clinical language, protocol structure, and evidence expectations that define this field. First-mover position in a category that medicine needs.

Clinical Foundation

Designed for surgical physiology

Every formulation decision addresses a specific physiologic domain of the perioperative period — built from first principles by a physician who understands what surgery demands from the human body, not adapted from a general wellness product.

Institutional Integration

Built into the clinical workflow

PERIOME integrates into ASC and hospital pre-operative workflows — physician-recommended and operationally embedded. A perioperative protocol placed where the patient already trusts: in the recommendation of their surgical team.

Patient Access

50 million reasons to scale

More than 50 million surgical procedures happen in the U.S. each year. PERIOME reaches surgical patients directly or through a referring clinician — the same structured perioperative protocol delivered at the point of care.

Now

Perioperative Nutritional Protocols

The evidence-grounded foundation. Formulated by a board-certified anesthesiologist for the physiologic demands of surgery — across procedure types, patient populations, and care settings. This is where PERIOME begins.

Wearable Integration & Perioperative Data

Wearable biosensors, continuous monitoring, and pre-operative biometric baselines will define how precisely we can understand a patient's physiologic readiness for surgery and their recovery trajectory. Data-informed perioperative optimization is the natural next layer.

Future

The Perioperative Resilience Index (PRI)

A standardized, clinician-informed metric for surgical readiness — accounting for nutritional status, physiologic reserve, and modifiable risk factors. A common clinical language for what "prepared for surgery" actually means.

Long-Term