A $200 billion surgical ecosystem. Zero readiness infrastructure. One company building it.
Fifty million surgical procedures happen annually in the United States. Almost none of the patients receive structured physiologic preparation for what surgery demands from the human body. PERIOME is the first company building the commercial infrastructure for that discipline.
Start the conversation →Three converging forces.
The perioperative preparation gap has existed for decades. Three converging forces make this the moment to build the infrastructure around it.
The perioperative preparation gap was not discovered in a market analysis. It was observed across thousands of surgical cases by the anesthesiologists who founded this company. The clinical subspecialty of perioperative medicine has matured to the point where the evidence base, the institutional receptivity, and the clinical workforce are ready to support a company that builds the infrastructure around it. The science has existed for decades. What was missing was the company willing to translate it into a standard of care.
The CMS TEAM mandate and the broader shift to episode-based payment mean that surgical programs are now financially responsible for outcomes that were previously absorbed by the system. Readmissions, complications, and extended recovery are no longer externalities — they are costs the institution bears. This did not create the perioperative gap. It created the financial consequence for ignoring it. The institutions that need PERIOME most are the ones now accountable for the outcomes PERIOME addresses.
The intelligence layer PERIOME is building — a system that integrates patient preparation data, physiologic status, and clinical context into a quantified readiness framework — requires technology infrastructure that has only recently become available at scale. The ability to personalize preparation, track adherence, and learn from every surgical outcome across an institutional deployment is what transforms a protocol company into a platform company. The technology is an accelerant. The clinical conviction came first.
Modern surgical care has three optimized pillars. The fourth has no owner.
The surgical procedure, the anesthesia plan, and the operating room environment have each been systematically refined over decades. The fourth pillar — perioperative medicine, the clinical discipline of optimizing human physiology across the full window of surgical stress — has received no equivalent investment. No specialty consistently owns it. No protocol addresses it at scale. No company has been built around it.
PERIOME is building the clinical infrastructure for the perioperative period — beginning with the preparation standard the surgical window has never had. The protocol is the entry point. What comes after it is the company.
"The Fourth Pillar of surgical excellence has no commercial owner. PERIOME intends to be that owner."
Public figures. CMS TEAM: 188 mandatory markets, January 2026 through 2030.
A $200B ecosystem. No standard of preparation.
No established standard of perioperative patient preparation exists in U.S. surgical care. PERIOME is building it.
The protocol is the entry point. The platform is the destination.
PERIOME's commercial architecture begins with the perioperative preparation standard — the structured patient readiness layer that surgical programs have never had. That foundation generates the institutional relationships, clinical credibility, and patient outcomes data that every subsequent layer of the platform is built on.
- 2023Origin Thesis
The founding clinical conviction, formed across thousands of surgical cases, becomes the company thesis. Formulation and clinical framework take shape.
- 2025Clinical Brief & Pilot Conversations
Clinical Brief, institutional pilot framework, first program conversations.
- 2026Founded & Protocol Launch
PERIOME, Inc. founded. PERIOME PROTOCOL general availability. Founding institutional pilots and the framework for the first outcomes cohort.
- NextThe Intelligence Platform
Perioperative Resilience Index™, perioperative genomics, recovery intelligence — the layers shared directly with qualified investors.
The details of the roadmap beyond the protocol are shared directly with qualified investors.
The dataset PERIOME generates does not exist anywhere in medicine today.
No EMR captures it. No payer aggregates it. No academic medical center has built the longitudinal pipeline. Every patient who prepares with PERIOME PROTOCOL generates structured perioperative data — preparation adherence, physiologic status, anesthetic outcomes, recovery trajectory — that aggregates across every program PERIOME deploys within. The protocol earns the institutional relationship. The data is the asset that compounds.
Why this category. Why this team. Why now.
The science is not new. Decades of peer-reviewed research in perioperative nutrition, surgical physiology, and prehabilitation document what surgery demands from the human body — and what structured preparation can do to improve how the body meets that demand. What was missing was not evidence. It was a company willing to build the clinical infrastructure, the protocol, and the institutional delivery system around it. PERIOME is that company.
Founded by two board-certified anesthesiologists who each identified the same physiologic gap across thousands of surgical cases — and built the company to close it. The conviction behind PERIOME is clinical, not theoretical. It was earned in the operating room.
What comes after the protocol is the platform. The Perioperative Resilience Index™ — a quantified readiness score that integrates preparation status, physiologic data, and clinical context into a single measure of surgical readiness — will give clinicians and institutions something perioperative medicine has never had: a standardized, comparable measure of whether the patient is prepared for what surgery demands. Every patient who uses the protocol generates the clinical signal that makes the platform more precise. Every institutional deployment builds the dataset. The protocol earns entry. The intelligence layer is the destination.
The go-to-market architecture places institutional credibility at the center. Clinical adoption drives patient access. Patient access drives outcomes data. Outcomes data drives the platform. The sequence matters — and it is intentional. The details of how that architecture compounds are shared with investors directly.
Built by people who have stood in that room.
PERIOME is co-founded by two board-certified anesthesiologists who observed the same clinical gap from thousands of combined cases — and built the company that addresses it.
Founder of PERIOME and The PERIOP Journal. Built PERIOME on a clinical observation that repeated itself across thousands of anesthetic cases: patients arriving physiologically underprepared in ways that were specific, addressable, and ignored by the care system surrounding them.
Dr. Hansen brings deep clinical experience in perioperative physiology and anesthetic management to PERIOME's medical and scientific direction. He oversees clinical framework development, formulation strategy, and the institutional deployment of PERIOME PROTOCOL.
Start the conversation.
PERIOME does not make its investor materials publicly available. If you are a qualified investor or institutional partner interested in the category-creation opportunity, reach out directly. Every inquiry is reviewed personally by the founding team.
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