For clinicians

Cleared is not the same as ready.

Clearance is a clinical decision made at one visit. The weeks between that visit and the operating room are mostly out of view: whether instructions were followed, what changed, what the patient never got to ask. PERIOME is building the system that carries the patient through those weeks and keeps the care team in the loop.

How to recommend PERIOME Bring PERIOME to your program

Between visits

Most surgical preparation happens where no clinician can see it.

Between the preoperative visit and the day of surgery, the patient is largely on their own: working through instructions, stopping and starting medications, deciding what is worth a phone call. After discharge, recovery moves home, and the next data point is often the post-op visit.

ERAS pathways already reach into these weeks, and the evidence behind them is strong. What is often missing is a consistent way to carry them out, patient by patient, and to know what actually happened.

The perioperative episode

Everything the team needs to know before the case.

See what changed, what was completed, and what remains unresolved—without losing the patient between visits.

PERIOME OS · Perioperative Health Infrastructure
Illustrative product environment Northstar Health System

Patient episodes

Perioperative episode · Total knee arthroplasty

Eleanor Reed · Surgery 18 Nov 2026 · 14 days to surgery

Planned pathway
Total joint · ASC
Episode owner
Perioperative RN
  1. UnderstandBaseline complete · 07 Oct
  2. Prepare3 open actions · now
  3. CareSurgery · 18 Nov
  4. RecoverFollow-up through day 90
  5. LearnEpisode closes with outcomes

Episode summary

6 connected sources
Readiness profile
Progressing5 of 6 domains on plan
Planned pathway
ASCSet by the surgical team
Planned stay
Same dayOvernight contingency available
Recovery destination
HomeSupport confirmed

Current attention

Hematologic follow-up before the readiness review.

Mobility plan needs final confirmation.

DomainCurrent stateTrendMost recent signalSource
Functional reserveMobility · capacityOn planStableSit-to-stand baseline recordedFunctional measures
CardiorespiratoryCapacity · symptomsOn planStableNo exertional symptoms reportedPatient-reported · EHR
HematologicHemoglobin · ironRequires reviewImprovingRepeat studies due 12 NovLaboratory
MetabolicGlucoseOn planStableHome readings within planEHR · patient-reported
NutritionIntake · proteinOn planStablePreparation days completed: 13 of 14Morton
Patient experienceQuestions · engagementOn planStableNo open questionsMorton

Perioperative Intelligence summary. Functional reserve is preserved and home support is confirmed. Hematologic follow-up is the current attention: repeat studies are due before the readiness review. The mobility plan remains open.

Open workflow

3 actions
  1. Repeat CBC and iron studies

    Results before the readiness review.

    Owner: Carla Moore, RN · Due 12 Nov
  2. Finalize mobility plan

    Assistive device and home route.

    Owner: Leo Brown, PT · Due 13 Nov
  3. Medication acknowledgment

    Patient reviews the plan in Morton.

    Owner: Patient · Due 15 Nov

Connected sources

Last update
EHR chart
4 min ago
Laboratory
Yesterday
Medication record
2 h ago
Patient-reported data
Today
Functional measures
07 Nov
Morton engagement
Today

Before, during, after

What the care team needs across the episode.

PERIOME is organized around three moments in the surgical episode. Before and after surgery, Morton (in pilot) and the PERIOME Protocol work with the patient today. Carrying that context into the operating room is being built.

Before surgery

Readiness, not just clearance.

Where the patient is starting, what is still modifiable in the time that remains, and whether the preparation pathway was actually followed.

At the time of surgery

The context that should arrive with the patient.

What changed since the preoperative visit, what was completed and what is still open, so better preparation complements the care the team already gives.

After surgery

Recovery against the patient's own baseline.

How the patient is recovering at home, what patient-reported outcomes show, and what that should teach the team about the next patient.

What PERIOME is building

One emerging system across the perioperative episode.

Built by anesthesiologists for the whole surgical team: surgeons, anesthesiologists, nurses and perioperative teams. Three parts of one system, each at its own stage.

Morton™

In pilot

The patient's guide from the day surgery is scheduled. It is designed to carry the care team's own instructions, confirm each day's preparation, route questions to the team, and follow recovery after discharge.

Named for William T. G. Morton, whose 1846 public demonstration of ether anesthesia helped usher surgery into a new era.

The PERIOME Protocol

Launch list open

A defined preparation across the surgical window: PREPARE before the operation, READY, an ERAS-aligned carbohydrate drink, on the day itself, and RECOVER afterward. Bounded by the operation, not a chronic supplement.

See the patient experience

Measurement

In development

Defining readiness and recovery against each patient's own starting point. The Perioperative Resilience Index™ is one proposed framework within this work, not yet validated.

How measurement works

Clinical boundaries

Built to fit clinical practice, not to work around it.

PERIOME is designed to support the care you already give, within the orders you already write.

  • Your orders firstThe surgical team's fasting and medication instructions come first, every time.
  • Your judgmentAppropriateness is decided by the clinician, against the medication profile and the surgical plan.
  • No outcome claimsStructure and function only. Claims will follow evidence, not precede it.
  • No added workflowNo prescription, no formulary addition, no portal.
  • Not a wellness productIt begins when surgery is scheduled and ends with recovery.

How to recommend it

One sentence, at a visit the patient is already having.

The protocol is recommended, not prescribed, so it fits whichever preoperative contact comes first.

  1. At any preoperative visit

    The surgeon's office, a primary care clearance visit, a pre-admission clinic or the pre-anesthesia evaluation; whichever comes first.

  2. For the right patient

    ASA I–III, elective or semi-elective, at least seven days before surgery.

  3. Point them to periome.com/patients

    One link to say out loud. Patients sign up directly, and ordering opens when the protocol ships.

  4. PERIOME carries the patient's side

    The protocol through the surgical window, with daily guidance and check-ins for patients in the Morton pilot.

The physiology

The clinical framework.

Six physiologic domains relevant to the surgical window: hydration and electrolytes; metabolic and recovery capacity; neurocognitive resilience; immune and inflammatory resilience; GI integrity and microbiome; micronutrient foundation.

Every ingredient was screened for antiplatelet, anticoagulant, glycemic and hemodynamic interaction risk, and reviewed for compatibility with commonly used anesthetic agents.

Full formulation and evidence

Physician-founded

Founded from inside perioperative care.

PERIOME was founded by two board-certified anesthesiologists, and it is built for the whole surgical team. Clinical champions help shape how it runs in their program. The standards for the field are being set by the Perioperative Health Council, not by PERIOME.

Bring PERIOME to your program