We are defininga new category.
PERIOME is the perioperative health company.
“Modern medicine has optimized the procedure. It has optimized the anesthesia. It has not optimized the patient entering surgery. That is the gap. That is the category. PERIOME is the company that defined it.
Chad R. Greene, D.O.Founder & CEO
Fifty million surgical procedures happen in the United States every year. Almost none of the patients who undergo them receive structured physiologic preparation for what surgery demands from the human body. The science to address this has existed for decades. What was missing was the company willing to build the infrastructure around it.
PERIOME is that company. Physician-founded, from inside the operating room, by two board-certified anesthesiologists who identified the same gap across thousands of cases — and built the infrastructure to close it. The clinical entry point is PERIOME PROTOCOL. The destination is the intelligence infrastructure that surgical programs, health systems, and payers have never had. We are building both — deliberately, from the inside out.
Defining Perioperative Medicine.
Building the clinical infrastructure perioperative medicine has never had.
Why this company. Why now.
The clinical evidence has existed for decades. What was missing was the infrastructure to deliver it at the point of care.
Decades of peer-reviewed research document the physiologic demands of surgical stress — and how nutritional preparation, metabolic support, and targeted supplementation can address them. The gap was never scientific. It was the absence of a company that translated that evidence into a protocol, a product, and a delivery system placed at the point of care.
The surgical procedure, the anesthesia plan, and the operating room environment have each been systematically built and operationalized over decades. Patient physiologic readiness — what the patient's body brings into the OR — has not. No specialty consistently owns this. No protocol addresses it. PERIOME is building the fourth pillar.
No clinical specialty owns the window between surgery scheduling and the OR. No established protocol addresses what a patient's physiology needs in the days before and after a procedure. PERIOME is building the clinical language, the protocol standard, and the evidence infrastructure for a field that has existed as background noise for decades.
PERIOME is designed to be recommended by the surgeon or anesthesiologist who understands what the procedure demands — not marketed around them. That recommendation carries clinical credibility. It reaches the patient at the moment they are most motivated to prepare. And it makes perioperative readiness part of the standard of care, not an afterthought.
Built from inside the operating room.
PERIOME was co-founded by two board-certified anesthesiologists who observed the same clinical gap from thousands of cases: patients arriving at surgery physiologically unprepared in ways that were specific, addressable, and completely unaddressed by the care system designed to protect them.
Founder & CEO
Chad R. Greene, D.O.
Board-Certified Anesthesiologist · Vanderbilt-Trained
Founded PERIOME on the clinical observation that perioperative medicine was the unbuilt fourth pillar of surgical care. Leads clinical strategy, formulation philosophy, institutional development, and platform architecture.
Co-Founder & President
Daniel Hansen, M.D.
Board-Certified Anesthesiologist · Mayo Clinic-Trained
Brings deep clinical experience in perioperative physiology and anesthetic management to PERIOME's medical and scientific direction. Oversees clinical framework development, formulation strategy, and the institutional deployment of PERIOME PROTOCOL.
PERIOME is forming its Clinical Advisory Council — the physicians, surgeons, anesthesiologists, and perioperative medicine specialists who will shape the clinical standards and outcomes infrastructure the company is building. Founding council members will be announced as those relationships are formalized.
clinical@periome.com →PERIOME is building its core team across clinical affairs, health system partnerships, and platform development. We are looking for physicians, operators, and builders who understand where perioperative care is going — and want to help determine what it becomes.
team@periome.com →Coverage of perioperative medicine — coming 2026. Press resources →
How we build.
These are not marketing values. They are the constraints that govern every formulation decision, every clinical claim, and every institutional conversation we have.
Every compound in PERIOME PROTOCOL has a perioperative mechanism. No ingredient was included for general wellness, marketing appeal, or category convention. The formulation reflects the best available published evidence at launch — and will be systematically updated as real-world outcomes data accumulates from institutional partners.
PERIOME is designed to be evaluated and deployed by surgeons, anesthesiologists, and ASC medical directors. Every clinical claim, every piece of copy, and every product decision is held to the standard of institutional review.
Every public claim is a structure/function claim compliant with 21 CFR Part 101 (DSHEA). No disease claims. No endorsement fabrications. No regulatory gray areas. The companies that cut corners on claims don't earn institutional trust. We don't cut corners.
The connected, measurable system PERIOME is building for perioperative medicine does not yet exist in any organized form. We are building the standard. That requires a different level of rigor than launching a product.
We will not optimize for DTC conversion at the expense of institutional credibility. We will not make claims we can't defend. We will not launch features before they're clinically sound. The goal is a company that serious surgical programs trust — and keep trusting as it grows.
PERIOME is being built by two physicians who are still practicing. That is not incidental. The clinical observation that drives this company is not historical — it repeats itself every week. That proximity to the problem is the company's most durable competitive advantage.
Built deliberately.
PERIOME is early. The clinical category we are building is not.
- 2023Clinical observation becomes company thesis
Across thousands of cases and two independent clinical practices, the same pattern emerged: patients arrived physiologically underprepared in ways that were specific and addressable. The science existed. The infrastructure did not. PERIOME begins as a thesis.
- 2024Formulation development and clinical review
Board-certified anesthesiologists and research scientists develop PERIOME PROTOCOL across six physiologic domains. Every compound selected for perioperative mechanism. Notable exclusions documented with clinical rationale.
- 2025Clinical Brief published. Institutional pathway launched.
PERIOME Clinical & Scientific Whitepaper published. Health systems and ASC inquiry pathway opens. Patent pending on the protocol. FDA-registered, cGMP-certified manufacturing partner confirmed.
- 2026PERIOME, Inc. founded. Protocol launch.
PERIOME, Inc. is founded. PERIOME PROTOCOL launches to the waitlist and initial institutional partners. Deployment framework established with ASC and health system programs.
- NextThe Perioperative Intelligence Platform. The Standard of Care.
The Perioperative Resilience Index™ quantifies readiness across six domains. Genomic intelligence personalizes that score to the individual patient's inherited biology. Morton™ — the Perioperative Intelligence Patient Companion — guides every patient through the full perioperative arc and monitors their recovery through day 90. PERIOME OS gives every institution a real-time intelligence dashboard for case readiness, cancellation risk, and outcomes performance. The data that every enrolled patient generates flows back into the system and makes the next patient better prepared. This is perioperative intelligence at scale.
Perioperative medicine has defined where surgical care is going. PERIOME is building the infrastructure to get there.
The direction is set by the specialty itself. Leading anesthesiologists and the field's own institutions have described a future where the perioperative window is a connected, measurable, continuously improving standard of care, not a gap between specialties. The evidence base for perioperative optimization has been accumulating for decades in the peer-reviewed literature. What the field has not had is a company that turns that direction into infrastructure at the point of care. That is what PERIOME is building.
Help define the standard.
The surgical programs, clinicians, and institutional leaders who engage with PERIOME early are not adopting a product — they are helping define the standard.