Surgery optimized the procedure. It never optimized the patient.
Fifty million Americans have surgery every year. Almost none receive structured physiologic preparation for it. PERIOME is the perioperative health company — optimizing human physiology before, during, and after surgery through clinically grounded preparation, recovery, and intelligence infrastructure.
Three pillars have been systematically optimized. The fourth has been systematically ignored.
The procedure. The anesthesia plan. The operating room. Each pillar has decades of refinement, dedicated infrastructure, and clinical specialization behind it. But the physiologic condition the patient brings into the operating room — their hydration status, nutritional baseline, mitochondrial reserve, gut integrity, neurocognitive resilience — has never had a discipline, a protocol, or a company responsible for it. Until now.
Under episode-based accountability models, the cost of that unaddressed variable falls directly on the institution.
Three phases. One compounding system.
PERIOME is built across the full perioperative arc. Each phase generates clinical value, patient data, and institutional intelligence that makes the next phase more powerful.
PERIOME PROTOCOL covers both windows. One continuous arc.
From the moment surgery is confirmed, patients receive the PERIOME PROTOCOL and structured preparation guidance. Physiologic baseline is built over the seven days before the patient enters the room — not the morning of.
Patient readiness data, preparation adherence, and relevant clinical context are available at the point of care — giving the anesthesiology and surgical team a more complete picture before the first incision.
Structured recovery support and outcome tracking generate the institutional intelligence that improves every subsequent patient. Each case makes the program stronger.
One protocol. The complete perioperative window.
A 14-day physician-formulated protocol — initiated seven days before surgery and continued through the first week of recovery. Structured across the five physiologic domains that surgical stress most directly challenges.
Prepare.
The protocol begins one week before surgery — taken once daily at home. Each daily dose addresses the physiological systems that surgical stress most directly depletes: electrolyte balance, mitochondrial energy, gut mucosal integrity, and neurocognitive resilience. Patients arrive at the hospital in the strongest physiologic condition they can be.
Final pre-operative dose timing follows NPO and fasting instructions from the surgical team.
Recover.
The protocol resumes once daily through the first week after surgery — when surgical catabolism, antibiotic exposure, and immune activation create the highest demand for physiologic support. Patients recover at home with the same structured clinical framework that prepared them.
The complete 14-day perioperative course.
Built on a decade of perioperative medicine.
From inside the operating room
PERIOME was co-founded by two board-certified anesthesiologists who identified the perioperative window as the most consistently neglected period in surgical care — and built the protocol to address it.
Every domain has a literature base
PERIOME PROTOCOL targets five physiological systems with peer-reviewed evidence for each ingredient: hydration, mitochondrial energy, cognition, gastrointestinal integrity, and microbiome resilience.
Deployed at the point of surgical scheduling
PERIOME enters the clinical workflow when surgery is confirmed — weeks before the pre-anesthesia evaluation, and long before the patient meets the anesthesia team. By the time the clinical picture is being assembled, the patient has already completed structured physiologic preparation.
Built for health system and surgical program deployment.
The outcome metrics PERIOME moves are the metrics surgical programs are now accountable for.
Readmissions. Complications. Length of stay. Recovery trajectory. These are no longer clinical data points alone — they are financial ones. PERIOME gives surgical programs the clinical infrastructure to address them at the source: the patient entering the room.
Designed for institutional deployment — not a product placement.
PERIOME’s institutional framework is a structured outcomes program built into the deployment from day one. The data belongs to the institution. The standard improves with every patient.
Every pilot is structured to generate publishable signal.
Outcome metrics — PONV incidence, PACU dwell time, discharge readiness, patient-reported recovery quality — are defined before deployment begins. Programs that partner early are building the evidence base for a category that does not yet have one.
Built from inside the operating room.
Both co-founders are practicing board-certified anesthesiologists. They identified the perioperative gap from thousands of cases — not from a whiteboard — and built the infrastructure to close it.
Dr. Greene founded PERIOME on a clinical conviction formed across thousands of cases: the perioperative window is the most consequential unaddressed period in surgical care, and the infrastructure to own it has never been built. He is building that infrastructure — from the first evidence-based perioperative protocol to the readiness assessment platform, genomic intelligence layer, and longitudinal outcomes infrastructure that will define how surgical programs prepare every patient they operate on — and fully recover every patient they send home. He leads clinical strategy, formulation philosophy, institutional partnerships, and platform architecture.
“The variable I can’t change at induction is the physiology the patient brings into the room. That was always the gap. PERIOME closes it.”
Dr. Hansen co-founded PERIOME to build the clinical and scientific architecture that will make perioperative health a recognized discipline in surgical medicine. From the formulation design of PERIOME PROTOCOL to the genomic precision layer that will personalize surgical preparation at the individual patient level, he sets the standard for what PERIOME builds, what it claims, and how it deploys alongside the surgical programs that are shaping the future of perioperative care.
“The perioperative literature is clear. The physiology is well understood. The gap has never been scientific — it has been the absence of a company that translated the evidence into a protocol and placed it at the point of care. That’s what we built.”
The science of perioperative preparation is settled. The clinical system to deliver it has not existed — until now.
Functional capacity, nutritional reserve, inflammatory load, autonomic tone — these are measurable. They predict surgical outcomes. They can be meaningfully shifted in the weeks before surgery. The physiology has been understood for decades. What has been missing is the infrastructure to act on it, systematically, before every case.
Explore the Science →Under value-based care, what happens before the first incision becomes the institution’s financial outcome.
Every patient. Every surgery. Prepared.
The preparation protocol. The readiness platform. The outcomes intelligence. Built by the clinicians who identified the gap from inside the operating room — and built the infrastructure to close it.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always follow your surgical team’s instructions.